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In addition to alkaloids, the leaves contain flavonoids such as lutein, apigenin, and rutin (300800 g/g of dry matter) and terpenes, including diterpenes and sesquiterpenes [19,20], all of which contribute to the plants insecticidal activity through their toxic effects and diverse chemical compositions, making tobacco a promising natural source of biopesticides

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According to his friend, personal assistant, and biographer Aniela Jaffe, in her book From the Life and Work of C.G